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    • The Ultimate Immune Defense Stack

      The Ultimate Immune Defense Stack is a synergistic blend of phytonutrients designed to support the immune system and prevent and protect against pathogenic cellular activity.

      MORINGA OLEIFERA

      Moringa oleifera is a potent nutrient to enhance immune system function. Any substance that can affect the part of the immune system known as the cytokine system is known as an immunomodulator. Researchers have determined that the diversity of vitamins, proteins, and polysaccharides found in the Moringa tree act as modulation in repairing the damaged cytokine communication pathways while improving other aspects of the immune system such as increasing production and activity levels of T cells, macrophages, natural killer cells leading to the subsequent production of interferon, interleukins and tumour necrotic factor.



      QUERCETIN

      Quercetin, a polyphenol flavonoid derived from plants, has a wide range of biological actions including anti-carcinogenic, anti-inflammatory, antiviral, antioxidant, and psychostimulant activities, as well as the ability to inhibit lipid peroxidation, platelet aggregation and capillary permeability, and to stimulate mitochondrial biogenesis. The zinc ionophore activity of quercetin facilitates the transport of zinc across the cell membrane and it is estblished that zinc will slow down the replication of virus genetic material through inhibition of enzyme RNA polymerase. Quercetin is a safe dietary supplement

      VITAMIN C

      Vitamin C is an essential micronutrient for humans, and has multiple functions related to its ability to be an electron donor. Vitamin C benefits immune system function by supporting multiple cellular functions involving both the innate and adaptive immune system. These benefits are: supporting epithelial barrier function against pathogens, enhancing differentiation and proliferation of B- and T-cells, promoting the oxidant scavenging activity of the skin protecting against oxidative stress, enhancing chemotaxis, phagocytosis, and generation of reactive oxygen species to kill pathogens. Vitamin C deficiency results in impaired immunity and higher susceptibility to infections. Furthermore, supplementation with vitamin C appears to be able to both prevent and treat respiratory and systemic infections.

    • VITAMIN D3

      Vitamin D has important immune system roles in addition to its effects on calcium and bone homeostasis. The vitamin D receptor is found on immune cells: B cells, T cells and antigen presenting cells. Vitamin D can modulate both the innate and adaptive immune responses.

      It should be noted that deficiency of vitamin D is associated with increased autoimmunity issues as well as an increased vulnerability to infection. There have been multiple studies linking lower levels of vitamin D with increased infection. The immune cells affecting autoimmune diseases are responsive to the beneficial effects of vitamin D. Further there have been a number of studies examining vitamin D levels and rates of influenza and other viral infections. All have reported an association of lower vitamin D levels and increased rates of infection, and in one study it was shown that a therapeutic dose of vitamin D resulted in a statistically significant (42%) decrease in the incidence of influenza infection.

      ZINC

      Supplementation with zinc and/or zinc ionophores, that help zinc enter the cell interior, has been shown to be essential to the support and maintenance of the human innate and adaptive immune system for decades. “The importance of zinc for human health has been recognized since the early 1960s. Zinc is an essential micronutrient required for the activity of more than 300 enzymes and 1,000 transcription factors and for the control of genetic expression. It also plays important roles in nucleic acid/protein synthesis, cell replication, and tissue growth and repair. Zinc deficiency is known to be associated with various pathological conditions, including impaired immunity, delayed wound healing, retarded growth, neural development disorders and degenerative diseases.”

       

      References

      Aguirre L., Arias N., Macarulla M.T., Gracia A., Portillo M.P. Beneficial effects of quercetin on obesity and diabetes. Open Nutraceuticals J. 2011;4:189–198

      Andreini C, Bertini I. A bioinformatics view of zinc enzymes. J Inorg Biochem 2012;111:150–6.

      Aranow C. (2011). Vitamin D and the immune system. Journal of investigative medicine : the official publication of the American Federation for Clinical Research59(6), 881–886.

      Carr AC, Maggini S. Vitamin C and Immune Function. Nutrients. 2017 Nov 3;9(11):1211. doi: 10.3390/nu9111211. PMID: 29099763; PMCID: PMC5707683.

      Fisher H W.  Moringa Oleifera: Magic Myth or Miracle.  Britannia Printers.  Toronto. 2012

      Jayavardhanan K K, K Suresh K, Panikkar K R, Vasudevan D M.  Modulatory potency of drumstick lectin on the host defense system. Journal of Experimental Clinical Cancer Research 1994;13(3):p.205-209

       Lambert SA, Jolma A, Campitelli LF, Das PK, Yin Y, Albu M, Chen X, Taipale J, Hughes TR, Weirauch MT. The human transcription factors. Cell 2018;172(4):650–65.

      Li, Y., Yao, J., Han, C., Yang, J., Chaudhry, M. T., Wang, S., Liu, H., & Yin, Y. (2016). Quercetin, Inflammation and Immunity. Nutrients8(3), 167. https://doi.org/10.3390/nu8030167

      Overbeck S, Rink L, Haase H. Modulating the immune response by oral zinc supplementation: a single approach for multiple diseases. Arch Immunol Ther Exp (Warsz) 2008;56(1):15–30.

      Prasad AS, Miale A, Jr., Farid Z, Sandstead HH, Schulert AR. Zinc metabolism in patients with the syndrome of iron deficiency anemia, hepatosplenomegaly, dwarfism, and hypogonadism. J Lab Clin Med 1963;61:537–49.

      Smith J E, Rowan N J, Sullivan R.  Medicinal mushrooms: their therapeutic properties and current medical usage with special emphasis on cancer treatments.  University of Strathclyde. 2002.

      te Velthuis AJ, van den Worm SH, Sims AC, Baric RS, Snijder EJ, van Hemert MJ. Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture. PLoS Pathog. 2010 Nov 4;6(11):e1001176.

      Urashima M, et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr. 2010;91(5):1255–60.

      Yamshchikov AV, et al. Vitamin D for treatment and prevention of infectious diseases: a systematic review of randomized controlled trials. Endocr Pract. 2009;15(5):438–49. [

      Yasuda, Hiroshi & Tsutsui, Toyoharu. (2016). Infants and elderlies are susceptible to zinc deficiency. Scientific Reports. 6. 21850. 10.1038/srep21850.
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